【脉铂医药】MedBio|2421119-60-8|JKE-1674技术资料

2021-08-17

1、JKE-1674基本信息：

Purity Specification: ≥98%

Molecular Formula :C20H20CL2N4O4

CAS Number: 2421119-60-8 Formula Weight : 451.3 Storage:-20°C Stability: ≥2 years

JKE-1674 is supplied as a crystalline solid. A stock solution may be made by dissolving the JKE-1674 in the solvent of choice, which should be purged with an inert gas. JKE-1674 is soluble in DMSO.

JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210 (Item No. MED24563). JKE-1674 reduces viability of LOX-IMVI cancer cells (EC50 =0.03 μM) and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 (Item No. MED14798).

2、JKE-1674物理化学性质：

密度	1.4±0.1 g/cm3
沸点	595.5±60.0 °C at 760 mmHg
分子式	C20H20Cl2N4O4
分子量	451.303
闪点	313.9±32.9 °C
精确质量	450.086151
LogP	3.35
蒸汽压	0.0±1.8 mmHg at 25°C
折射率	1.651

3、JKE-1674英文别名：

1,2-Propanedione, 1-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-3-nitro-, 2-oxime, (2E)-

(2E)-1-{4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}-2-(hydroxyimino)-3-nitro-1-propanone

JKE-1674

货号	产品名称	品牌	规格型号	包装	目录价	数量	购物车
MED27642	JKE-1674 (mixture of isomers) ,2421119-60-8	MedBio	≥98%	1mg	¥877.00
MED27642	JKE-1674 (mixture of isomers) ,2421119-60-8	MedBio	≥98%	5mg	¥3098.00