【脉铂医药】MedBio|1532533-67-7|TGR-1202 厄布利塞技术资料

TGR-1202 厄布利塞英文别名：(S)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

1、Umbralisib用途：

Umbralisib (TGR-1202) 是 PI3Kδ 抑制剂，IC50 和 EC50 值分别为 22.2 nM 和 24.3 nM；Umbralisib (TGR-1202) 同时可抑制 CK1ε，EC50 值为 6.0 μM。

2、Umbralisib​​​​​​​物理化学性质：

3、Umbralisib​​​​​​​参考文献：  

[1]. Swaroop Vakkalankaa, et al. Inhibition of PI3Kδ kinase by a selective, small molecule inhibitor suppresses B-cell proliferation and leukemic cell growth.

[2]. Deng C, et al. Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies. Blood. 2017 Jan 5;129(1):88-99

4、Umbralisib​​​​​​​英文别名：

(S)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one